A preliminary X-ray study of murine Tnfaip8/Oxi-α.

Daeun Lee, Mi-Sun Kim, Jimin Park, Gil-Ja Jhon, Jin H Son, Dong Hae Shin

International journal of molecular sciences 2014 Mar 14

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Tnfaip8/oxidative stress regulated gene-α (Oxi-α) is a novel protein expressed specifically in brain dopaminergic neurons and its over-expression has been reported to protect dopaminergic cells against OS-induced cell death. In this study, murine C165S mutant Tnfaip8/Oxi-α has been crystallized and X-ray data have been collected to 1.8 Å using synchrotron radiation. The crystal belonged to the primitive orthorhombic space group P21212, with unit-cell parameters a = 66.9, b = 72.3, c = 93.5 Å. A full structural determination is under way in order to provide insights into the structure-function relationships of this protein.

Citation

Daeun Lee, Mi-Sun Kim, Jimin Park, Gil-Ja Jhon, Jin H Son, Dong Hae Shin. A preliminary X-ray study of murine Tnfaip8/Oxi-α. International journal of molecular sciences. 2014 Mar 14;15(3):4523-30