Genetic characterization of a novel duck-origin picornavirus with six 2A proteins.

A novel virus was detected from diseased ducks and completely determined. The virus was shown to have a picornavirus-like genome layout. Interestingly, the genome contained a total of up to six 2As, including four 2As (2A1-2A4) each having an NPGP motif, an AIG1-like 2A5, and a parechovirus-like 2A6. The 5'UTR was predicted to possess a hepacivirus/pestivirus-like internal ribosome entry site (IRES). However, the subdomain IIIe consisted of a 3 nt stem and five unpaired bases, distinct from those found in all other HP-like IRESs. The virus was most closely related to duck hepatitis A virus, with amino acid identities of 37.7 %, 39 % and 43.7 % in the P1, P2 and P3 regions, respectively. Based on these investigations, together with phylogenetic analyses, the virus could be considered as the founding member of a novel picornavirus genus that we tentatively named 'Aalivirus', with 'Aalivirus A' as the type species.

Citation

Xiaoyan Wang, Ning Liu, Fumin Wang, Kang Ning, Yanbo Li, Dabing Zhang. Genetic characterization of a novel duck-origin picornavirus with six 2A proteins. The Journal of general virology. 2014 Jun;95(Pt 6):1289-96

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PMID: 24659102

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