New myxothiazols from the predatory bacterium Myxococcus fulvus.

Sebastian Schieferdecker, Thomas E Exner, Harald Gross, Martin Roth, Markus Nett

The Journal of antibiotics 2014 Jul

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Extracts of the predatory bacterium Myxococcus fulvus HKI 722 showed promising antimicrobial activities in the agar diffusion assay. A combined chemical and computational analysis led to the identification of five thiazole-containing antibiotics. Two of the isolated compounds represent previously unrecognized members of the myxothiazol family of natural products. Their antibiotic properties were determined in comparison with those of the known myxothiazols A and Z.

Citation

Sebastian Schieferdecker, Thomas E Exner, Harald Gross, Martin Roth, Markus Nett. New myxothiazols from the predatory bacterium Myxococcus fulvus. The Journal of antibiotics. 2014 Jul;67(7):519-25