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Phosphodiesterase-4 (PDE-4) regulates the intracellular level of cyclic adenosine monophosphate. Recent studies demonstrated that PDE-4 inhibitors can counteract deficits in long-term memory caused by aging or increased expression of mutant forms of human amyloid precursor proteins, and can influence the process of memory function and cognitive enhancement. Therapeutics, such as ketamine, a drug used in clinical anesthesia, can also cause memory deficits as adverse effects. Targeting PDE-4 with selective inhibitors may offer a novel therapeutic strategy to prevent, slow the progress, and, eventually, treat memory deficits.


Sheng Peng, Haiyan Sun, Xiaoqing Zhang, Gongjian Liu, Guanglei Wang. Effects of selective phosphodiesterases-4 inhibitors on learning and memory: a review of recent research. Cell biochemistry and biophysics. 2014 Sep;70(1):83-5

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PMID: 24699857

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