Risk assessment visualization of rubidium compounds: comparison of renal and hepatic toxicities, in vivo.

Kan Usuda, Rei Kono, Takaaki Ueno, Yuichi Ito, Tomotaro Dote, Hirotaka Yokoyama, Koichi Kono, Junko Tamaki

Biological trace element research 2014 Jun

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Rubidium has been considered to be nontoxic. Its use includes thin film on glass deposition and as medical contrast medium. Recent technology innovations also involve the use of rubidium, but there is limited information about the biological effects of its various compounds. In the present risk assessment study, a series of rubidium compounds with different counter anions-acetate, bromide, carbonate, chloride, and fluoride-were orally administrated in a single dose to several groups of rats. Cumulative 24-h urine samples were obtained, and the levels of rubidium, fluoride, N-acetyl-β-D-glucosaminidase and creatinine were measured to evaluate possible acute renal effects. Daily samples of serum were also obtained to determine the levels of aspartate and alanine aminotransferases to assess possible acute hepatic effects. Urinary rubidium excretion recovery of 8.0-10.5% shows that urine can be a useful diagnostic tool for rubidium exposure. The present results reveal that rubidium shows different biological effects depending on the counter anion. A pattern of large significant NAG leakage and elevation of ALT observed in rats treated with anhydrous rubidium fluoride indicates renal and hepatic toxicities that can be attributed to fluoride. The techniques reported in this study will be of help to assess the potential risks of toxicity of rubidium compounds with a variety of anions.

Citation

Kan Usuda, Rei Kono, Takaaki Ueno, Yuichi Ito, Tomotaro Dote, Hirotaka Yokoyama, Koichi Kono, Junko Tamaki. Risk assessment visualization of rubidium compounds: comparison of renal and hepatic toxicities, in vivo. Biological trace element research. 2014 Jun;159(1-3):263-8