Persistent and acute chlamydial infections induce different structural changes in the Golgi apparatus.

Huiling Zhu, Hongmei Li, Pu Wang, Mukai Chen, Zengwei Huang, Kunpeng Li, Yinyin Li, Jian He, Jiande Han, Qinfen Zhang

International journal of medical microbiology : IJMM 2014 Jul

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Chlamydia trachomatis causes a wide range of diseases that have a significant impact on public health. Acute chlamydial infections can cause fragmentation of the Golgi compartment ensuring the lipid transportation from the host cell. However, the changes that occur in the host cell Golgi apparatus after persistent infections are unclear. Here, we examined Golgi-associated gene (golga5) transcription and expression along with the structure of the Golgi apparatus in cells persistently infected with Chlamydia trachomatis. The results showed that persistent infections caused little fragmentation of the Golgi. The results also revealed that Golgi fragmentation might be associated with the suppression of transcription of the gene golga5. Copyright © 2014 Elsevier GmbH. All rights reserved.

Citation

Huiling Zhu, Hongmei Li, Pu Wang, Mukai Chen, Zengwei Huang, Kunpeng Li, Yinyin Li, Jian He, Jiande Han, Qinfen Zhang. Persistent and acute chlamydial infections induce different structural changes in the Golgi apparatus. International journal of medical microbiology : IJMM. 2014 Jul;304(5-6):577-85