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The search for novel anticonvulsants with more selectivity and lower toxicity continues to be an area of intensive investigation in medicinal chemistry. The potency and selectivity in the pharmacological response of quinazolines as anticonvulsant have attracted the attention of many researchers to explore this framework for its potential. It is, therefore, topic of interest to study development of new synthetic strategies and their anticonvulsant potential based on the most recent knowledge emerging from the latest research. This review reports current progress in the area of new biologically active quinazoline scaffold as potent anticonvulsant. It is a sincere attempt to compile the synthetic and design aspects of quinazoline derivatives with significant anticonvulsant action. This structural class of compound can prove to be useful for the design and development of potent anticonvulsant agents. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Citation

Vinod G Ugale, Sanjay B Bari. Quinazolines: new horizons in anticonvulsant therapy. European journal of medicinal chemistry. 2014 Jun 10;80:447-501

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PMID: 24813877

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