I2-catalyzed oxidative cross-coupling of methyl ketones and benzamidines hydrochloride: a facile access to α-ketoimides.

Xia Wu, Qinghe Gao, Shan Liu, Anxin Wu

Organic letters 2014 Jun 6

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An iodine-catalyzed oxidative cross-coupling of C-H/N-H has been demonstrated. This simple and efficient approach constructed α-ketoimides in good to excellent yields from methyl ketones and benzamidines hydrochloride under metal-free and peroxide-free conditions. This synthetic strategy was achieved via an in situ iodination-based oxidative coupling pathway.

Citation

Xia Wu, Qinghe Gao, Shan Liu, Anxin Wu. I2-catalyzed oxidative cross-coupling of methyl ketones and benzamidines hydrochloride: a facile access to α-ketoimides. Organic letters. 2014 Jun 6;16(11):2888-91