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Mannitol is commonly used to lower intracranial and intraocular pressures. Large doses/massive infusions of mannitol have been found to be associated with acute renal failure (MI-ARF), that is, osmotic nephrosis. While many researchers have reported individual experiences with this pathology, we felt that there is need of an updated comprehensive review of all reported cases with elaboration of etiology, pathogenesis, diagnosis and management plan for MI-ARF. The purpose of the present communication is to share our own experience with MI-ARF, to review the effect of mannitol on kidney function and to highlight the dynamics of MI-ARF with considerations for the cautious use of mannitol in patients with risk factors for kidney diseases.


Ali Zohair Nomani, Zahid Nabi, Humayun Rashid, Jamal Janjua, Hanna Nomani, Azer Majeed, Sohail Raza Chaudry, Ayesha Saad Mazhar. Osmotic nephrosis with mannitol: review article. Renal failure. 2014 Aug;36(7):1169-76

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PMID: 24941319

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