99mTc(Cu)-mannitol complex: a new agent for dynamic renal function studies.

U P Chauhan, J Chander, P Mishra, R C Sarin, R V Narayanan, B Singh

Institute of Nuclear Medicine and Allied Sciences, Delhi-, India.

International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1989

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Mannitol has been labeled with 99mTc by using cuprous chloride as a reducing agent. Blood and kidney clearance of 99mTc(Cu)-mannitol was slightly faster than that of 99mTc(Sn)-DPTA in rat and maximum radioactivity ratio of kidneys to blood was 84.6 at 5 min. A comparative study of 99mTc(Cu)-mannitol, 99mTc(Sn)-DTPA was made in rabbits by taking serial images of kidneys and bladder with a gamma camera. Results show superiority of 99mTc(Cu)-mannitol over other agents for dynamic renal function studies.

Citation

U P Chauhan, J Chander, P Mishra, R C Sarin, R V Narayanan, B Singh. 99mTc(Cu)-mannitol complex: a new agent for dynamic renal function studies. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. 1989;16(3):283-9