Correlation Engine 2.0
Clear Search sequence regions


  • cells (2)
  • cellular (2)
  • dna (5)
  • dna viral (2)
  • dna viral (2)
  • dna virus (2)
  • foreign (3)
  • host (2)
  • host responses (1)
  • humans (1)
  • inhibit (1)
  • insight (1)
  • pathogen (1)
  • viruses (1)
  • Sizes of these terms reflect their relevance to your search.

    Mammalian cells detect foreign DNA introduced as free DNA or as a result of microbial infection, leading to the induction of innate immune responses that block microbial replication and the activation of mechanisms that epigenetically silence the genes encoded by the foreign DNA. A number of DNA sensors localized to a variety of sites within the cell have been identified, and this review focuses on the mechanisms that detect viral DNA and how the resulting responses affect viral infections. Viruses have evolved mechanisms that inhibit these host sensors and signaling pathways, and the study of these antagonistic viral strategies has provided insight into the mechanisms of these host responses. The field of cellular sensing of foreign DNA is in its infancy, but our currently limited knowledge has raised a number of important questions for study.

    Citation

    Megan H Orzalli, David M Knipe. Cellular sensing of viral DNA and viral evasion mechanisms. Annual review of microbiology. 2014;68:477-92

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 25002095

    View Full Text