Phenolic compounds from leaves of Casimiroa edulis showed adipogenesis activity.

Hiroyuki Nagai, Toshiyuki Tanaka, Tsuyoshi Goto, Tatsuya Kusudo, Nobuyuki Takahashi, Teruo Kawada

Bioscience, biotechnology, and biochemistry 2014

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Casimiroa edulis is known as cochitzapotl, and it belongs to a species of tropical fruiting tree in the family Rutaceae, native to eastern Mexico and Central America south to Costa Rica. In this study, we isolated two furocoumarins and two polymethoxyflavones from leaves of C. edulis and evaluated the functions of glucose and lipid metabolism activity with 3T3-L1 adipocytes. We discovered that the addition of furocoumarins increased glucose uptake and lipid accumulation in 3T3-L1 adipocyte. These results suggest that furocoumarin compounds can be used as functional food-derived compounds, to regulate adipocyte functioning for the management of metabolic syndrome, which is associated with dysfunctions of glucose and lipid metabolism.

Citation

Hiroyuki Nagai, Toshiyuki Tanaka, Tsuyoshi Goto, Tatsuya Kusudo, Nobuyuki Takahashi, Teruo Kawada. Phenolic compounds from leaves of Casimiroa edulis showed adipogenesis activity. Bioscience, biotechnology, and biochemistry. 2014;78(2):296-300