Clinical experience with long-term acetazolamide treatment in children with nondystrophic myotonias: a three-case report.

Joekie M Markhorst, Bas C Stunnenberg, Ieke B Ginjaar, Gea Drost, Corrie E Erasmus, Lilian T L Sie

Pediatric neurology 2014 Oct

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Today, treatment of the nondystrophic myotonias consists of mexiletine, although care has to be taken because of the proarrhythmogenic potential of this drug. In this article, we report years of experience with the carbonic anhydrase inhibitor acetazolamide. We present three children with nondystrophic myotonias. During acetazolamide treatment, symptoms and signs of myotonia decreased in our children. Based on this clinical experience and the favorable pharmacologic profile of acetazolamide, it may be a good treatment option for children with nondystrophic myotonias. Copyright © 2014 Elsevier Inc. All rights reserved.

Citation

Joekie M Markhorst, Bas C Stunnenberg, Ieke B Ginjaar, Gea Drost, Corrie E Erasmus, Lilian T L Sie. Clinical experience with long-term acetazolamide treatment in children with nondystrophic myotonias: a three-case report. Pediatric neurology. 2014 Oct;51(4):537-41