Tryptophan-containing dipeptides are C-domain selective inhibitors of angiotensin converting enzyme.

Diana Lunow, Susanne Kaiser, Jana Rückriemen, Christoph Pohl, Thomas Henle

Food chemistry 2015 Jan 1

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Somatic angiotensin-converting enzyme (ACE) contains two active sites, the C- and N-domain, from which the C-domain is supposed to play a major role in blood pressure regulation and is therefore a promising pharmacological target to reduce blood pressure without side-effects. We report for the first time that tryptophan-containing dipeptides such as Ile-Trp or Val-Trp, which were recently found in food protein hydrolysates, are selective and competitive inhibitors for the C-domain with a selectivity factor of 40 and 70, respectively. Structure-activity studies showed that an N-terminal aliphatic amino acid and a tryptophan moiety in the P2' position are favourable structures for C-domain inhibition in dipeptides. In contrast, the lactotripeptides Ile-Pro-Pro and Val-Pro-Pro, which were widely used as ingredients for hypotensive food, showed a slight selectivity for the N-domain. Hence, tryptophan containing dipeptides are interesting ingredients for functional foods as a natural prevention for hypertension with reduced side effects due to its selective inhibition of the C-domain. Copyright © 2014 Elsevier Ltd. All rights reserved.

Citation

Diana Lunow, Susanne Kaiser, Jana Rückriemen, Christoph Pohl, Thomas Henle. Tryptophan-containing dipeptides are C-domain selective inhibitors of angiotensin converting enzyme. Food chemistry. 2015 Jan 1;166:596-602