6-Perfluoroalkylated phenanthridines via radical perfluoroalkylation of isonitriles.

Bo Zhang, Armido Studer

Organic letters 2014 Aug 1

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A simple and efficient approach to 6-perfluoroalkylated phenanthridines starting with readily prepared isonitriles and commercially available cheap perfluoroalkyl iodides as perfluoroalkyl radical precursors is described. Various 6-perfluoroalkylated phenanthridines are obtained in moderate to excellent yields. The sequence comprises a perfluoroalkylation with concomitant arene formation.

Citation

Bo Zhang, Armido Studer. 6-Perfluoroalkylated phenanthridines via radical perfluoroalkylation of isonitriles. Organic letters. 2014 Aug 1;16(15):3990-3