Correlation Engine 2.0
Clear Search sequence regions


  • b7 antigens (2)
  • butyrophilins (6)
  • cells (1)
  • fat (1)
  • glycolipids (2)
  • glycoproteins (4)
  • homeostasis (1)
  • humans (1)
  • mice (1)
  • milk (2)
  • t lymphocytes (1)
  • Sizes of these terms reflect their relevance to your search.

    The B7 family of co-stimulatory molecules has an important role in driving the activation and inhibition of immune cells. Evolving data have shown that a related family of molecules - the butyrophilins - have similar immunomodulatory functions to B7 family members and may represent a novel subset of co-stimulatory molecules. These studies have taken the field by surprise, as the butyrophilins were previously thought to only be important in lactation and milk production. In this Review, we describe the expression patterns of the various members of the butyrophilin family and explore their immunomodulatory functions. In particular, we emphasize the contribution of butyrophilins to immune homeostasis and discuss the potential of targeting these molecules for therapeutic purposes.

    Citation

    Heather A Arnett, Joanne L Viney. Immune modulation by butyrophilins. Nature reviews. Immunology. 2014 Aug;14(8):559-69

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 25060581

    View Full Text