Ni-catalyzed carboxylation of unactivated primary alkyl bromides and sulfonates with CO2.

A Ni-catalyzed carboxylation of unactivated primary alkyl bromides and sulfonates with CO2 at atmospheric pressure is described. The method is characterized by its mild conditions and remarkably wide scope without the need for air- or moisture-sensitive reagents, which make it a user-friendly and operationally simple protocol en route to carboxylic acids.

Citation

Yu Liu, Josep Cornella, Ruben Martin. Ni-catalyzed carboxylation of unactivated primary alkyl bromides and sulfonates with CO2. Journal of the American Chemical Society. 2014 Aug 13;136(32):11212-5

PMID: 25068174

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