The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism.

Moritz Jacobshagen, Mathieu Niquille, Séverine Chaumont-Dubel, Philippe Marin, Alexandre Dayer

Development (Cambridge, England) 2014 Sep

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The formation of a laminar structure such as the mammalian neocortex relies on the coordinated migration of different subtypes of excitatory pyramidal neurons in specific layers. Cyclin-dependent kinase 5 (Cdk5) is a master regulator of pyramidal neuron migration. Recently, we have shown that Cdk5 binds to the serotonin 6 receptor (5-HT6R), a G protein-coupled receptor (GPCR). Here, we investigated the role of 5-HT6R in the positioning and migration of pyramidal neurons during mouse corticogenesis. We report that constitutive expression of 5-HT6R controls pyramidal neuron migration through an agonist-independent mechanism that requires Cdk5 activity. These data provide the first in vivo evidence of a role for constitutive activity at a GPCR in neocortical radial migration. © 2014. Published by The Company of Biologists Ltd.

Citation

Moritz Jacobshagen, Mathieu Niquille, Séverine Chaumont-Dubel, Philippe Marin, Alexandre Dayer. The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism. Development (Cambridge, England). 2014 Sep;141(17):3370-7