Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus.

Sheng-Jie Yu, En-Chih Liao, Jaw-Ji Tsai

Immunobiology 2014 Dec

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Although many patients with SLE also have allergies, the immunological events triggering the onset and progression of the clinical manifestations of SLE by allergens have yet to be clarified. A total of three autoantigens, phosphoglycerate kinase 1 (PGK-1), triosephosphate isomerase (TIM) and enolase were identified by autologous serum in B cell lysate derived from HDM allergic SLE patients after Der p 2 stimulation. Autoantigen, TRIM-21 expression were also significantly increased in B cells derived from HDM allergic SLE patients. In PBMCs derived from SLE patients, the concentration of anti-PGK-1 was significantly upregulated after Der p 2 stimulation compared to HDM allergic without SLE patients and healthy subjects. Inflammatory related cytokines and chemokines include IL-1β, IL-6, IL-8, CXCL5 could be upregulated after Der p 2 stimulation in PBMCs derived from HDM allergic SLE patients. In conclusion, our data demonstrated that long-term allergen exposure could be a contributing factor in the development of SLE. Copyright © 2014 Elsevier GmbH. All rights reserved.

Citation

Sheng-Jie Yu, En-Chih Liao, Jaw-Ji Tsai. Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus. Immunobiology. 2014 Dec;219(12):958-63