Non-standard similarity/dissimilarity analysis of DNA sequences.

Piotr Wąż, Dorota Bielińska-Wąż

Genomics 2014 Dec

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Similarity/dissimilarity analysis of DNA sequences is performed using 3D-dynamic representation. The sequences are represented by material points in a 3D-space. Descriptors related to such 3D-dynamic graphs are calculated. A new normalized similarity measure is introduced for a comparison of the sequences. The method is applied to β-globin (HBB) genes of different species. Different methods are compared. The multidimensionality of similarity space of complex objects is discussed (different results for each of the methods). It is also shown that it is easier to find the properties which are consistent with the observation of the evolution of the species for the second exons of β-globin gene rather than for the first ones. Copyright © 2014 Elsevier Inc. All rights reserved.