myo-Inositol 1,3-acetals as early intermediates during the synthesis of cyclitol derivatives.

Bharat P Gurale, Richa S Sardessai, Mysore S Shashidhar

Carbohydrate research 2014 Nov 18

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Synthetic sequences starting from commercially available myo-inositol necessarily involve protection-deprotection strategies of its six hydroxyl groups. Several strategies have been developed/attempted over the last several decades leading to the synthesis of naturally occurring phosphoinositols, their analogs, and cyclitol derivatives. Of late, myo-inositol 1,3-acetals, which can be obtained by the reductive cleavage of myo-inositol orthoesters have emerged as early intermediates for the synthesis of phosphorylated and other inositol derivatives. This mini-review is an attempt to illustrate the economy and convenience of using myo-inositol 1,3-acetals as early intermediates during syntheses from myo-inositol.

Citation

Bharat P Gurale, Richa S Sardessai, Mysore S Shashidhar. myo-Inositol 1,3-acetals as early intermediates during the synthesis of cyclitol derivatives. Carbohydrate research. 2014 Nov 18;399:8-14