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During spermiogenesis, histones are massively replaced with protamines. A previous report showed that Drosophila males homozygous for a genomic deletion covering several genes including the protamine-like genes Mst35Ba/b are surprisingly fertile. Here, we have precisely deleted the Mst35B locus by homologous recombination, and we confirm the dispensability of Mst35Ba/b for fertility. Copyright © 2014 Tirmarche et al.


Samantha Tirmarche, Shuhei Kimura, Laure Sapey-Triomphe, William Sullivan, Frédéric Landmann, Benjamin Loppin. Drosophila protamine-like Mst35Ba and Mst35Bb are required for proper sperm nuclear morphology but are dispensable for male fertility. G3 (Bethesda, Md.). 2014 Sep 17;4(11):2241-5

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PMID: 25236732

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