Correlation Engine 2.0
Clear Search sequence regions

  • adult (1)
  • chest tube (1)
  • diagnosis (5)
  • empyema (1)
  • humans (1)
  • hydrogen ion (1)
  • il 8 (1)
  • interleukin 1β (1)
  • interleukin 1β (2)
  • Interleukin 8 (4)
  • LD (4)
  • over (1)
  • patients (2)
  • PFLD (3)
  • pneumonia (2)
  • ROC (1)
  • serum (1)
  • young adult (1)
  • Sizes of these terms reflect their relevance to your search.

    Thirty percent of patients with pneumonia develop pleural effusion, and of these, 20% have complicated effusion (CPPE), which may require a chest tube or surgery for resolution. The objective of the study is to compare the diagnostic yield of determining interleukin-1β and interleukin-8 in pleural fluid (PF) (PFIL-1β and PFIL-8) with respect to classic criteria (pH <7.2, lactate dehydrogenase [LD] >1,000 IU/mL, and/or glucose <60 mg/dL) in the early diagnosis of CPPE. Of the 559 patients studied, 40 had CPPE. All underwent PF analysis: pH, glucose (PFGLUC), LD (PFLD), PFIL-1β and PFIL-8, and PF/serum ratios (PF/SIL-1β and PF/SIL-8). The diagnostic criterion that showed the best area under the curve was the combination of PF/SIL-8 and PFIL-1β (0.906), with a statistically significant difference (P < .05) compared with the classic criterion of pH and PFGLUC or PFLD (0.826). The combination of PF/SIL-8 and PFIL-1β (cutoffs >5.73 and >9.14 pg/mL, respectively) was significantly more sensitive (72.7%) and more specific (97.9%) (P < .05) than the rest of the parameters used. Measurement of IL-1β and IL-8 in pleural fluid may be useful in the early diagnosis of CPPE, although individually, it may not improve the results obtained with the PFLD. Further studies are needed to more firmly establish what role these new parameters can play in the diagnosis of CPPE. Copyright© by the American Society for Clinical Pathology.


    M Esther San José, Lucia Ferreiro, M Esther Soneira, Francisco J González-Barcala, M Carmen Vázquez, Antonio Golpe, Luis Valdés. Utility of measurement of interleukin-1ß and interleukin-8 in the diagnosis of complicated parapneumonic pleural effusions. American journal of clinical pathology. 2014 Oct;142(4):467-73

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 25239413

    View Full Text