Correlation Engine 2.0
Clear Search sequence regions

  • adult (1)
  • bipolar disorder (9)
  • cellular (3)
  • female (1)
  • growth factors (2)
  • hamilton (1)
  • humans (2)
  • lithium (6)
  • male (1)
  • neurotrophin 4 (12)
  • neurotrophin 5 (3)
  • NT 4/ 5 (9)
  • NT- 3 (11)
  • patients (3)
  • phase (1)
  • plasma (2)
  • young adult (1)
  • Sizes of these terms reflect their relevance to your search.

    Bipolar disorder (BD) has been associated with diverse abnormalities in neural plasticity and cellular resilience. Neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5) support synaptic neuronal survival and differentiation. NT-3 and NT-4/5 levels were found to be altered in BD, potentially representing a physiological response against cellular stress. However, the use of psychopharmacological agents and heterogeneous mood states may constitute important biases in such studies. Thus, we aimed to assess NT-3 and NT-4/5 levels in medication-free BD type I or II individuals in a current depressive episode, before and after 6 weeks of lithium monotherapy and matched with healthy controls. Twenty-three patients with BD type I or II during a depressive episode and 28 healthy controls were studied. Patients were required to have a 21-item Hamilton Depression Rating Scale score ≥18 and had not undergone any psychopharmacological treatment for at least 6 weeks prior to study entry. Patients were treated with lithium for 6 weeks and plasma NT-3 and NT-4/5 levels were determined at baseline and endpoint using ELISA method. Baseline plasma levels of both NT-3 and NT-4/5 were significantly increased in acutely depressed BD subjects in comparison to healthy controls (p=0.040 and 0.039, respectively). The NT-3 and NT-4/5 levels did not significantly change after lithium treatment. NT-3 and NT-4/5 levels were positively correlated to illness duration in BD (p=0.032 and 0.034, respectively). Our findings suggest that NT-3 and NT-4/5 levels are increased in the depressive phase of BD, which seems directly associated with illness duration. The increased levels of NT-3 and NT-4/5 may underlie a biological response to cellular stress associated with the course of BD. Copyright © 2014 Elsevier Inc. All rights reserved.


    Alexandre A Loch, Marcus V Zanetti, Rafael T de Sousa, Tiffany M Chaim, Mauricio H Serpa, Wagner F Gattaz, Antonio L Teixeira, Rodrigo Machado-Vieira. Elevated neurotrophin-3 and neurotrophin 4/5 levels in unmedicated bipolar depression and the effects of lithium. Progress in neuro-psychopharmacology & biological psychiatry. 2015 Jan 2;56:243-6

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 25290636

    View Full Text