Correlation Engine 2.0
Clear Search sequence regions

  • behavior (1)
  • cancer (8)
  • cell (6)
  • dna (2)
  • efs protein, human (1)
  • Fyn (7)
  • genes (3)
  • humans (1)
  • male (1)
  • men (1)
  • metastasis (1)
  • phosphoproteins (2)
  • prostate (11)
  • protein human (1)
  • research (1)
  • signal (2)
  • suppressor gene cancer (1)
  • tumor suppressor (2)
  • Sizes of these terms reflect their relevance to your search.

    Prostate cancer is the most frequently diagnosed malignant neoplasm in men in the developed countries. Although the progression of prostate cancer and the processes of invasion and metastasis by tumor cells are comparatively well understood, the genes involved in these processes are not fully determined. Therefore, a common area of research interest is the identification of novel molecules that are involved in these processes. In the present study, we have used in silico and experimental approaches to compare the expression of embryonal Fyn-associated substrate (EFS) between normal prostate and prostate cancer. We showed that EFS expression is remarkably downregulated in prostate cancer cells, compared to normal prostate cells. We also found that decreased expression of EFS in prostate cancer cells is due to DNA methylation. In addition, we showed that high EFS expression is important to suppress a malignant behavior of prostate cancer cells. Therefore, we suggest that EFS should be considered as a novel tumor suppressor gene in prostate cancer.


    Selda Sertkaya, Syed Muhammad Hamid, Nihat Dilsiz, Lokman Varisli. Decreased expression of EFS is correlated with the advanced prostate cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2015 Feb;36(2):799-805

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 25296736

    View Full Text