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    The tert-butyl hydroperoxide (TBHP)-promoted sequential carboxamidation and aromatisation of isonitriles with formamides was developed. This procedure tolerates a series of functional groups, such as methyl, fluoro, chloro, acetyl, methoxy carbonyl and cyano. This reaction involved the addition of formamide radicals to isonitriles and sequential C-C bond formation by intramolecular aromatic cyclisation, leading to phenanthridine 6-carboxamides in moderate to good yields.


    Xiaomei Feng, Hui Zhu, Lei Wang, Yan Jiang, Jiang Cheng, Jin-Tao Yu. TBHP-promoted sequential carboxamidation and aromatisation of aryl isonitriles with formamides. Organic & biomolecular chemistry. 2014 Dec 7;12(45):9257-63

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    PMID: 25302870

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