TBHP-promoted sequential carboxamidation and aromatisation of aryl isonitriles with formamides.

Xiaomei Feng, Hui Zhu, Lei Wang, Yan Jiang, Jiang Cheng, Jin-Tao Yu

Organic & biomolecular chemistry 2014 Dec 7

filter terms:

The tert-butyl hydroperoxide (TBHP)-promoted sequential carboxamidation and aromatisation of isonitriles with formamides was developed. This procedure tolerates a series of functional groups, such as methyl, fluoro, chloro, acetyl, methoxy carbonyl and cyano. This reaction involved the addition of formamide radicals to isonitriles and sequential C-C bond formation by intramolecular aromatic cyclisation, leading to phenanthridine 6-carboxamides in moderate to good yields.

Citation

Xiaomei Feng, Hui Zhu, Lei Wang, Yan Jiang, Jiang Cheng, Jin-Tao Yu. TBHP-promoted sequential carboxamidation and aromatisation of aryl isonitriles with formamides. Organic & biomolecular chemistry. 2014 Dec 7;12(45):9257-63