Recent results in the search for new molecules with ambergris odor.

Johannes Panten, Horst Surburg, Bernd Hölscher

Chemistry & biodiversity 2014 Oct

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The synthesis of new odorant molecules is still a challenging task for the fragrance chemist, because now as ever it is difficult to predict the odor properties of small organic molecules. Therefore, certain tools, such as, e.g., lead-structure optimization of existing odorants, are helpful techniques. In this article, we describe the synthesis and the odor properties of a new molecule derived by the so-called 'seco' lead-structure optimization of the ambergris compound Ambroxide(®) . Based on these results, more representatives with similar structures have been synthesized and evaluated for their olfactory properties. Copyright © 2014 Verlag Helvetica Chimica Acta AG, Zürich.

Citation

Johannes Panten, Horst Surburg, Bernd Hölscher. Recent results in the search for new molecules with ambergris odor. Chemistry & biodiversity. 2014 Oct;11(10):1639-50