RING finger protein 4 (RNF4) derepresses gene expression from DNA methylation.

RNF4 is an E3 ubiquitin ligase originally identified as a transcription co-activator. The mechanism by which RNF4 promotes transcription remains unclear. In this study, I found that RNF4 antagonizes transcriptional repression mediated by DNA methylation. RNF4 does not promote DNA demethylation, but mediates the ubiquitination of MeCP2, a methyl-CpG-binding domain (MBD) protein. Removal of MeCP2 from gene promoters activates transcription. This study thus not only uncovers how RNF4 functions as a transcription activator, but also reveals the mechanism by which MeCP2 protein stability is regulated. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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Yu Wang. RING finger protein 4 (RNF4) derepresses gene expression from DNA methylation. The Journal of biological chemistry. 2014 Dec 05;289(49):33808-13

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PMID: 25355316

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