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Synthesis of bicyclic guanidines via cascade hydroamination/Michael additions of mono-N-acryloylpropargylguanidines.
Ki-Hyeok Kwon, Catherine M Serrano, Michael Koch, Louis R Barrows, Ryan E Looper
Organic letters 2014 Dec 5Sizes of these terms reflect their relevance to your search.
A cascade silver(I)-catalyzed hydroamination/Michael addition sequence has been developed to deliver highly substituted bicyclic guanidines. This transformation gives rise to geometrically and constitutionally stable ene-guanidines and generates a remote stereocenter with moderate to high diastereoselectivity.
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Ki-Hyeok Kwon, Catherine M Serrano, Michael Koch, Louis R Barrows, Ryan E Looper. Synthesis of bicyclic guanidines via cascade hydroamination/Michael additions of mono-N-acryloylpropargylguanidines. Organic letters. 2014 Dec 5;16(23):6048-51
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PMID: 25393831
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