A simple and robust preparation of N-acetylindoxyls: precursors for indigogenic substrates.

Michael N Gandy, Lindsay T Byrne, Keith A Stubbs

Organic & biomolecular chemistry 2015 Jan 21

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A generalised, simple and efficient synthesis of N-acetyl-5-bromo-4-chloroindoxyl and related analogues required for the synthesis of indigogenic substrates to probe for biological activities is reported. The method is both synthetically and operationally simple and represents a significant improvement on existing methods.

Citation

Michael N Gandy, Lindsay T Byrne, Keith A Stubbs. A simple and robust preparation of N-acetylindoxyls: precursors for indigogenic substrates. Organic & biomolecular chemistry. 2015 Jan 21;13(3):905-8