B Zmbova, D Djokić, V Bogdanova, I Tadzer, B Ajdinović, M Rastovac
Institute for Radioisotopes, Boris Kidric Institute of Nuclear Sciences, Vinca, Belgrade, Yugoslavia.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1989A procedure is described for the synthesis of p-[(bisacarboxymethyl)aminomethyl carbamino] hippuric acid (PAHIDA). The compound was identified by i.r. and NMR spectroscopy. A lyophilized complex was prepared and labeled with 99mTc. The purity of the preparation is better than 98%. The stability of the 99mTc-PAHIDA complex is achieved 8 h after labeling. Biodistribution tested on white rats shows a maximum accumulation in kidneys of 6-10% within 2 min after injection, while the accumulation in the liver is 2-4% of the administrated dose. Preliminary clinical studies of 99mTc-PAHIDA on patients and its comparison with 131I-hippuran showed that the 99Tc-PAHIDA preparation has excellent characteristics for visualization of kidneys. However, it has slightly slower urinary elimination compared to hippuran, which it makes possible to use PAHIDA as a replacement of hippuran to a certain extent.
B Zmbova, D Djokić, V Bogdanova, I Tadzer, B Ajdinović, M Rastovac. Synthesis of p-aminohippuric acid analog and its labeling by technetium-99m. International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes. 1989;40(3):225-34
PMID: 2541109
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