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Aurora kinase family is a group of serine/threonine protein kinase. It is the main regulator in mitosis, including centrosome regulation, spindle formation, and chromosome separation. Aurora-A is an oncogene that is highly expressed in various human tumors, including osteosarcoma. Its high expression level and malignance and tumor metastasis are correlated. Aurora-A is a potential tumor marker. The progress of Aurora-A kinase in tumor research is summarized in this article.


Xiaozhong Zhu, Jiong Mei, Zhiyuan Wang. Aurora-A kinase: potential tumor marker of osteosarcoma. Journal of cancer research and therapeutics. 2014 Nov;10 Suppl:C102-7

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PMID: 25450266

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