Inhibition of malaria parasite growth by quinomycin A and its derivatives through DNA-intercalating activity.

Hiroki Hayase, Nobumoto Watanabe, Chung Liang Lim, Toshihiko Nogawa, Keisuke Komatsuya, Kiyoshi Kita, Hiroyuki Osada

Bioscience, biotechnology, and biochemistry 2015

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Quinomycin A and its derivatives were identified as potent antimalarial (Plasmodium falciparum) agents in a screen of the RIKEN NPDepo chemical library. IC50 values of quinomycin A and UK-63,598 were approximately 100 times lower than that of the antimalarial drug chloroquine. This activity was mitigated by the addition of plasmid DNA, suggesting that these compounds act against parasites by intercalating into their DNA.

Citation

Hiroki Hayase, Nobumoto Watanabe, Chung Liang Lim, Toshihiko Nogawa, Keisuke Komatsuya, Kiyoshi Kita, Hiroyuki Osada. Inhibition of malaria parasite growth by quinomycin A and its derivatives through DNA-intercalating activity. Bioscience, biotechnology, and biochemistry. 2015;79(4):633-5