Genetic variants in let-7/Lin28 modulate the risk of oral cavity cancer in a Chinese Han population.

Let-7 and Lin28 establish a double-negative feedback loop to affect several biological processes, such as differentiation of stem cell, invasion and metastasis, and tumorigenesis. In this study, we systematically investigated the associations between 6 potentially functional SNPs of let7 and Lin28 genes and the risk of oral cavity cancer with a case-control study including 384 oral cavity cancer cases and 731 controls. We found that the variant allele (T) of rs221636 of Lin28B was significantly associated with a reduced risk of oral cavity cancer [odds ratio (OR) = 0.73, 95% confidence interval (CI) = 0.58-0.92, P = 7.55 × 10(-3) in additive model]. Bioinformatics prediction indicated that rs221636 was located at the binding site of hsa-miR-548p in the 3' UTR of Lin28B. Luciferase activity assay also showed a lower expression level for rs221636 T allele compared with A allele. These findings indicated that rs221236 located at Lin28B may contribute to the risk of oral cavity cancer through the interruption of miRNA binding.

Citation

Yu Zhang, Longbiao Zhu, Ruixia Wang, Limin Miao, Hongbing Jiang, Hua Yuan, Hongxia Ma, Ning Chen. Genetic variants in let-7/Lin28 modulate the risk of oral cavity cancer in a Chinese Han population. Scientific reports. 2014 Dec 11;4:7434

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PMID: 25503985

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