Twist-BRD4 complex: potential drug target for basal-like breast cancer.

Jian Shi, Jingying Cao, Binhua P Zhou

Current pharmaceutical design 2015

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As an important basic helix-loop-helix (bHLH) transcription factor, Twist associates with several physiological processes such as mesodermal development, and pathological processes such as Saethre-Chotzen syndrome. During cancer progression, Twist induces epithelial-mesenchymal transition (EMT), potentiating cancer cell invasion and metastasis. Although many studies have revealed its multiple biological roles, it remained unclear how Twist transcriptionally activates targeted genes. Recently we discovered tip60-mediated Twist di-acetylation in the ''histone H4-mimic'' GK-X-GK motif. The di-acetylated Twist recruits BRD4 and related transcriptional components to super-enhancer of its targeted genes during progression of basal-like breast cancer (BLBC). Here, we review this new advance of regulation and functional mechanism of Twist.

Citation

Jian Shi, Jingying Cao, Binhua P Zhou. Twist-BRD4 complex: potential drug target for basal-like breast cancer. Current pharmaceutical design. 2015;21(10):1256-61