Physico-chemical study of the radiopharmaceuticals 99mTc-DMSA, 99mTc-EDTA and 99mTc-DTPA interaction with plasmatic proteins.

R Garcia Domenech, O Abril Mendez, J Galvez Alvarez, A Farga Marti

School of Pharmacy, Department of Chemical Physics, University of Valencia, Spain.

International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1989

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This report studies the binding rate of the radiopharmaceuticals 99mTc-DTPA, 99mTc-EDTA and 99mTc-DMSA to plasmatic proteins. The proteins bind to the tested radiopharmaceuticals in the following sequence: 99mTc-DTPA less than 99mTc-DMSA(C1) less than 99mTc-EDTA less than 99mTc-DMSA(C2) where C1 and C2 represent two different Tc-DMSA complexes. The thermodynamic study suggests a quantitative relationship of radiopharmaceutical:protein = 1:1 and an almost nonexistent influence of the temperature, which means that the interacting forces in this process are relatively weak.

Citation

R Garcia Domenech, O Abril Mendez, J Galvez Alvarez, A Farga Marti. Physico-chemical study of the radiopharmaceuticals 99mTc-DMSA, 99mTc-EDTA and 99mTc-DTPA interaction with plasmatic proteins. International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes. 1989;40(6):536-8