The electronic structure of erythromycin A (ERYMA) molecule has been studied by UV photoelectron spectroscopy and assigned (in the low ionization energy region only) by empirical arguments. The two orbitals with highest energy (lowest ionization energy) are localized on the nitrogen of the desosamine sugar functional group and on the ester group of macrolide (lactone) ring. We discuss how these orbital energies can help to rationalize the known mode of binding of ERYMA to their biological receptors. Copyright © 2014 Elsevier B.V. All rights reserved.
Igor Novak, Branka Kovač. Electronic structure of antibiotic erythromycin. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2015 Mar 5;138:550-2
PMID: 25528514
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