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    This study investigated some T helper cytokines' association with different ANA positive sera. Sera of 53 ANA-positive subjects (11 were stained of homogeneous pattern, 12 of speckled particle pattern, 9 of nucleolar pattern, 15 of centromere pattern, and 6 of the peripheral nuclear type) were collected and analyzed by ELISA for related cytokines and concentrations were compared with each other and 16 healthy donors. Investigated cytokines including IL-12(p70) and IFN-γ varied differently in the ANA sera. This study demonstrated that some T helper cytokines varied with different ANA-positive sera, suggesting that they may play different roles in related autoimmune diseases. Copyright © 2014 Elsevier B.V. All rights reserved.


    Jinhui Hu, Yuyan Zhang, Xinghui Liu, Li Wei, Denghai Zhang. Relationship between certain T helper cytokines and ANA staining: who is the helper? International immunopharmacology. 2015 Feb;24(2):208-10

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    PMID: 25533500

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