Targeting of γ-tubulin complexes to microtubule organizing centers: conservation and divergence.

Tien-chen Lin, Annett Neuner, Elmar Schiebel

Trends in cell biology 2015 May

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Organisms with closed or open mitosis have differentially evolved various gamma-tubulin complex (γ-TuC) recruiting factors to organize diverse cellular microtubule (MT) arrays, including the mitotic spindle. γ-TuC recruiting factors not only target the γ-TuC to MT nucleation sites, but also regulate MT nucleation activity by generating the template for MT nucleation or promoting the MT nucleation activity of pre-existing γ-tubulin ring complexes (γ-TuRCs). Here we outline the current understanding of MT nucleator assembly and its regulation by γ-tubulin small complex (γ-TuSC) receptors. Moreover, we discuss the emergence of γ-TuC recruiting factors through evolution with augmented complexity and diversity and propose a hypothesis to account for the evolution of these factors in cooperative spindle assembly. Copyright © 2014 Elsevier Ltd. All rights reserved.

Citation

Tien-chen Lin, Annett Neuner, Elmar Schiebel. Targeting of γ-tubulin complexes to microtubule organizing centers: conservation and divergence. Trends in cell biology. 2015 May;25(5):296-307