Increased CD11b(+) Gr-1(+) cell population in the placenta after infection with Toxoplasma gondii.

Kinuko Takeshima, Kazuki Sato, Tsukasa Nabekura, Kisaburo Nagamune, Hiromi Hamada, Hiroyuki Yoshikawa, Akira Shibuya, Kazuko Shibuya

Microbiology and immunology 2015 Feb

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Toxoplasma gondii is an obligate intracellular protozoan pathogen that can cross the placenta, resulting in congenital toxoplasmosis with severe fetal brain abnormalities. The molecular mechanisms of immune responses against T. gondii infection in the placenta have largely remained unclear. An analytical method for characterizing phenotypes of immune cells in the placenta by flow cytometry was established and it was found that numbers of CD11b(+) Gr-1(+) cells in the placenta increased significantly after T. gondii infection. These results suggest that innate immune responses play an important role in immunity against T. gondii infection via the feto-maternal interface. © 2015 The Societies and Wiley Publishing Asia Pty Ltd.

Citation

Kinuko Takeshima, Kazuki Sato, Tsukasa Nabekura, Kisaburo Nagamune, Hiromi Hamada, Hiroyuki Yoshikawa, Akira Shibuya, Kazuko Shibuya. Increased CD11b(+) Gr-1(+) cell population in the placenta after infection with Toxoplasma gondii. Microbiology and immunology. 2015 Feb;59(2):95-8