Correlation Engine 2.0
Clear Search sequence regions

  • drug targets (1)
  • humans (1)
  • oncogenes (1)
  • Pim (10)
  • Pim 1 (1)
  • STAT (2)
  • Sizes of these terms reflect their relevance to your search.

    Pim oncogenes are highly expressed in many types of hematological and solid cancers. Pim kinases regulate the network of signaling pathways that are critical for tumorigenesis and development, making Pim kinases the attractive drug targets. Currently, two approaches have been employed in designing Pim kinase inhibitors: ATP-mimetics and non-ATP mimetics; but all target the ATP-binding pocket and are ATP-competitive. In this review, we summarize the current progress in understanding the Pim-related structure and biology, and provide insights into the binding modes of some prototypical Pim-1 inhibitors. The challenges as well as opportunities are highlighted for development of Pim kinase inhibitors as potential anticancer agents.


    Bich Thuy Le, Malika Kumarasiri, Julian R J Adams, Mingfeng Yu, Robert Milne, Matthew J Sykes, Shudong Wang. Targeting Pim kinases for cancer treatment: opportunities and challenges. Future medicinal chemistry. 2015;7(1):35-53

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 25582332

    View Full Text