Opioid and chemokine receptor crosstalk: a promising target for pain therapy?

Stéphane Mélik Parsadaniantz, Cyril Rivat, William Rostène, Annabelle Réaux-Le Goazigo

Nature reviews. Neuroscience 2015 Feb

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Chemokines and opioids are important regulators of immune, inflammatory and neuronal responses in peripheral and central pain pathways. Recent studies have provided insights into the functional interactions between chemokine receptors and opioid receptors, and their role in pain modulation. In this Progress article, we discuss how crosstalk between these two systems might provide a molecular and cellular framework for the development of novel analgesic therapies for the management of acute and/or chronic pain.

Citation

Stéphane Mélik Parsadaniantz, Cyril Rivat, William Rostène, Annabelle Réaux-Le Goazigo. Opioid and chemokine receptor crosstalk: a promising target for pain therapy? Nature reviews. Neuroscience. 2015 Feb;16(2):69-78