Spata6 is required for normal assembly of the sperm connecting piece and tight head-tail conjunction.

Shuiqiao Yuan, Clifford J Stratton, Jianqiang Bao, Huili Zheng, Bhupal P Bhetwal, Ryuzo Yanagimachi, Wei Yan

Proceedings of the National Academy of Sciences of the United States of America 2015 Feb 3

filter terms:

Pinhead sperm," or "acephalic sperm," a type of human teratozoospermia, refers to the condition in which ejaculate contains mostly sperm flagella without heads. Family clustering and homogeneity of this syndrome suggests a genetic basis, but the causative genes remain largely unknown. Here we report that Spata6, an evolutionarily conserved testis-specific gene, encodes a protein required for formation of the segmented columns and the capitulum, two major structures of the sperm connecting piece essential for linking the developing flagellum to the head during late spermiogenesis. Inactivation of Spata6 in mice leads to acephalic spermatozoa and male sterility. Our proteomic analyses reveal that SPATA6 is involved in myosin-based microfilament transport through interaction with myosin subunits (e.g., MYL6).

Citation

Shuiqiao Yuan, Clifford J Stratton, Jianqiang Bao, Huili Zheng, Bhupal P Bhetwal, Ryuzo Yanagimachi, Wei Yan. Spata6 is required for normal assembly of the sperm connecting piece and tight head-tail conjunction. Proceedings of the National Academy of Sciences of the United States of America. 2015 Feb 3;112(5):E430-9