NLP-12 engages different UNC-13 proteins to potentiate tonic and evoked release.

A neuropeptide (NLP-12) and its receptor (CKR-2) potentiate tonic and evoked ACh release at Caenorhabditis elegans neuromuscular junctions. Increased evoked release is mediated by a presynaptic pathway (egl-30 Gαq and egl-8 PLCβ) that produces DAG, and by DAG binding to short and long UNC-13 proteins. Potentiation of tonic ACh release persists in mutants deficient for egl-30 Gαq and egl-8 PLCβ and requires DAG binding to UNC-13L (but not UNC-13S). Thus, NLP-12 adjusts tonic and evoked release by distinct mechanisms. Copyright © 2015 the authors 0270-6474/15/351038-05$15.00/0.

Citation

Zhitao Hu, Amy B Vashlishan-Murray, Joshua M Kaplan. NLP-12 engages different UNC-13 proteins to potentiate tonic and evoked release. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015 Jan 21;35(3):1038-42

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PMID: 25609620

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