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Recent studies have compelled further interest in the potential pathological role of B cells in chronic graft-versus-host disease (cGVHD). In patients with cGVHD, B cells are activated and primed for survival via B-cell activating factor and B-cell receptor-associated pathways. Understanding the signaling pathways that drive immune pathology in cGVHD will facilitate the development of new strategies to selectively target aberrantly activated B cells and restore normal B-cell homeostasis after allogeneic stem cell transplantation. © 2015 by The American Society of Hematology.
Citation
Stefanie Sarantopoulos, Jerome Ritz. Aberrant B-cell homeostasis in chronic GVHD. Blood. 2015 Mar 12;125(11):1703-7
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PMID: 25645355
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