Correlation Engine 2.0
Clear Search sequence regions

  • acid (4)
  • brain (1)
  • calcium (1)
  • chickens (1)
  • dry weight (1)
  • edema (1)
  • feed (1)
  • food chain (1)
  • hydrogen ion (1)
  • liver (1)
  • magnesium (1)
  • magnesium silicates (2)
  • muscle (1)
  • necrosis (1)
  • phosphate (1)
  • time factors (1)
  • uranium (9)
  • uranyl nitrate (4)
  • Sizes of these terms reflect their relevance to your search.

    The use of phosphate mineral products in animal nutrition, as a major source of phosphor and calcium, can lead to uranium entering the food chain. The aim of the present study was to determine the protective effect of natural sepiolite and sepiolite treated with acid for broilers after oral intake of uranium. The broilers were contaminated for 7 days with 25 mg/uranyl nitrate per day. Two different adsorbents (natural sepiolite and sepiolite treated with acid) were given via gastric tube immediately after the oral administration of uranium. Natural sepiolite reduced uranium distribution by 57% in kidney, 80% in liver, 42% in brain, and 56% in muscle. A lower protective effect was observed after the administration of sepiolite treated with acid, resulting in significant damage of intestinal villi in the form of shortening, fragmentation, and necrosis, and histopathological lesions on kidney in the form of edema and abruption of epithelial cells in tubules. When broilers received only sepiolite treated with acid (no uranyl nitrate), shortening of intestinal villi occurred. Kidney injuries were evident when uranium concentrations in kidney were 0.88 and 1.25 µg/g dry weight. It is concluded that adding of natural sepiolite to the diets of broilers can reduce uranium distribution in organs by significant amount without adverse side effects.


    Branislava M Mitrović, Milijan Jovanović, Mirjana Lazarević-Macanović, Djordje Janaćković, Nikola Krstić, Mirjana Stojanović, Milorad Mirilović. Efficiency of sepiolite in broilers diet as uranium adsorbent. Radiation and environmental biophysics. 2015 May;54(2):217-24

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 25652083

    View Full Text