Inhibition of antiplatelet effects of aspirin by nonopioid analgesics.

T Hohlfeld, K Schrör

Clinical pharmacology and therapeutics 2015 Feb

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In patients undergoing coronary bypass grafting, we noticed that low-dose aspirin failed to inhibit platelet aggregation, potentially elevating the risk of thrombotic bypass occlusion. This "high on-treatment platelet reactivity" was reproducible in vitro and could be transferred with patient plasma or urine to aspirin-sensitive donor platelets, suggesting a drug/drug interaction. Loss of aspirin efficacy was associated with analgesia by dipyrone (metamizol) and initiated further study of the interaction between aspirin and other nonopioid analgesics. © 2014 American Society for Clinical Pharmacology and Therapeutics.

Citation

T Hohlfeld, K Schrör. Inhibition of antiplatelet effects of aspirin by nonopioid analgesics. Clinical pharmacology and therapeutics. 2015 Feb;97(2):131-4