Correlation Engine 2.0
Clear Search sequence regions

  • analgesia (1)
  • aspirin (7)
  • donor (1)
  • humans (1)
  • metamizol (1)
  • nonopioid analgesics (2)
  • patients (2)
  • plasma (1)
  • platelet (4)
  • vitro (1)
  • Sizes of these terms reflect their relevance to your search.

    In patients undergoing coronary bypass grafting, we noticed that low-dose aspirin failed to inhibit platelet aggregation, potentially elevating the risk of thrombotic bypass occlusion. This "high on-treatment platelet reactivity" was reproducible in vitro and could be transferred with patient plasma or urine to aspirin-sensitive donor platelets, suggesting a drug/drug interaction. Loss of aspirin efficacy was associated with analgesia by dipyrone (metamizol) and initiated further study of the interaction between aspirin and other nonopioid analgesics. © 2014 American Society for Clinical Pharmacology and Therapeutics.


    T Hohlfeld, K Schrör. Inhibition of antiplatelet effects of aspirin by nonopioid analgesics. Clinical pharmacology and therapeutics. 2015 Feb;97(2):131-4

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 25670517

    View Full Text