HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell growth in hepatocellular carcinoma.

Kun Gao, Chen Xu, Xiaofeng Jin, Reziya Wumaier, Jian Ma, Jingtao Peng, Yuqi Wang, Yan Tang, Long Yu, Pingzhao Zhang

Biochemical and biophysical research communications 2015 Mar 20

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HDGFRP2 (HRP-2) belongs to the Hepatoma-derived growth factor (HDGF)-related proteins (HRPs) family, which are characterized by a conserved HATH/PWWP domain at a well-conserved region of the N-terminus. However, the cellular function of HRP-2 remains unknown. In this study, we showed for the first time that HRP-2 is frequently overexpressed in human HCC tissues at mRNA and protein levels. We further showed that HRP-2 can promote HCC cells growth in vitro and xenograft tumors in vivo. Using protein affinity purification methods, we searched for functional partners of HRP-2, and found that HRP-2 interacts with various proteins known to be involved in transcription elongation and processing. Furthermore, we demonstrate HRP-2 interacts and co-localizes with RNA processing regulator IWS1, and positively regulated the mRNA level of Cyclin D1. Together, our study suggests HRP-2 may act as an mRNA processing co-factor to promote cells growth by regulating the mRNA of key oncogenes, which can be explored further for cancer treatment. Copyright © 2015 Elsevier Inc. All rights reserved.

Citation

Kun Gao, Chen Xu, Xiaofeng Jin, Reziya Wumaier, Jian Ma, Jingtao Peng, Yuqi Wang, Yan Tang, Long Yu, Pingzhao Zhang. HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell growth in hepatocellular carcinoma. Biochemical and biophysical research communications. 2015 Mar 20;458(4):849-55