p130Cas/BCAR1 scaffold protein in tissue homeostasis and pathogenesis.

BCAR1 (also known as p130Cas/BCAR1) is an adaptor protein that belongs to the CAS family of scaffold proteins. In the past years, increasing evidence has demonstrated the ability of p130Cas/BCAR1 to activate signaling originating from mechanical stimuli, cell-extracellular matrix (ECM) adhesion and growth factor stimulation cascades during normal development and disease in various biological models. In this review we will specifically discuss the more recent data on the contribution of p130Cas/BCAR1 in the regulation of tissue homeostasis and its potential implications in pathological conditions. Copyright © 2015 Elsevier B.V. All rights reserved.

Citation

Maria del Pilar Camacho Leal, Marianna Sciortino, Giusy Tornillo, Shana Colombo, Paola Defilippi, Sara Cabodi. p130Cas/BCAR1 scaffold protein in tissue homeostasis and pathogenesis. Gene. 2015 May 10;562(1):1-7

Mesh Tags

Substances

PMID: 25727852

search → result