Correlation Engine 2.0
Clear Search sequence regions

  • Antimigration (1)
  • bind (1)
  • Ca 2 (5)
  • calmodulin (5)
  • coumarins (2)
  • humans (1)
  • NFATc1 (4)
  • osteoclasts (3)
  • praeruptorin (8)
  • rank ligand (2)
  • RANKL (1)
  • signal (1)
  • vitro (4)
  • Sizes of these terms reflect their relevance to your search.

    Excessive activity and/or increased number of osteoclasts lead to bone resorption-related disorders. Here, we investigated the potential of praeruptorin A to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo. Praeruptorin A inhibited the RANKL-induced migration/fusion of preosteoclasts accompanied by the nuclear translocation of NFATc1, a master regulator of osteoclast differentiation. Antimigration/fusion activity of praeruptorin A was also confirmed by evaluating the mRNA expression of fusion-mediating molecules. In silico binding studies and several biochemical assays further revealed the potential of praeruptorin A to bind with Ca(2+)/calmodulin and inhibit its downstream signaling pathways, including the Ca(2+)/calmodulin-CaMKIV-CREB and Ca(2+)/calmodulin-calcineurin signaling axis responsible for controlling NFATc1. In vivo application of praeruptorin A significantly reduced lipopolysaccharide-induced bone erosion, indicating its possible use to treat bone resorption-related disorders. In conclusion, praeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis.


    Jeong-Tae Yeon, Sik-Won Choi, Byung Jun Ryu, Kwang-Jin Kim, Joo Yun Lee, Byung Jin Byun, Young-Jin Son, Seong Hwan Kim. Praeruptorin A inhibits in vitro migration of preosteoclasts and in vivo bone erosion, possibly due to its potential to target calmodulin. Journal of natural products. 2015 Apr 24;78(4):776-82

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 25734761

    View Full Text